Frailty and sarcopenia metabolomic signatures in kidney transplant candidates: the FRAILMar study.

ABSTRACT:

Background

Sarcopenia and frailty are often overlooked in assessing kidney transplant (KT) candidates with chronic kidney disease (CKD), potentially leading to poor post-transplant outcomes. This study aimed to identify metabolites associated with frailty and sarcopenia in KT candidates from the FRAILMar study.

Methods

Between June 2016 and June 2020, we evaluated frailty and sarcopenia in 173 KT candidates using the Physical Frailty Phenotype and EGWSOP-2 criteria, respectively. Seventy-five metabolic markers from targeted pathways, previously linked to CKD, sarcopenia or frailty, were measured in serum samples. These markers were analyzed using adjusted and weighted generalized linear models. Metabolomic data were integrated with multi-modal data, such as comorbidities, us

SUBMITTER: Madrid-Gambin F 

PROVIDER: S-EPMC11852263 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature