Propionate and butyrate counteract renal damage and progression to chronic kidney disease.

ABSTRACT:

Background

Short-chain fatty acids (SCFAs), mainly acetate, propionate and butyrate, are produced by gut microbiota through fermentation of complex carbohydrates that cannot be digested by the human host. They affect gut health and can contribute at the distal level to the pathophysiology of several diseases, including renal pathologies.

Methods

SCFA levels were measured in chronic kidney disease (CKD) patients (n = 54) at different stages of the disease, and associations with renal function and inflammation parameters were examined. The impact of propionate and butyrate in pathways triggered in tubular cells under inflammatory conditions was analysed using genome-wide expression assays. Finally, a pre-clinical mouse model of folic acid-induced transition from acute kidney i

SUBMITTER: Corte-Iglesias V 

PROVIDER: S-EPMC11852269 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature