Nutritional outcomes between different techniques of intradialytic amino acid replacement: a randomized controlled trial.

ABSTRACT:

Background

Amino acid (AA) depletion during dialysis deteriorates the protein-energy status of haemodialysis (HD) patients. This study aimed to determine whether intradialytic amino acid (IDAA) replacement by continuous infusion versus acute load could provide better nutritional outcomes.

Methods

HD patients with mild protein-energy wasting, defined as a serum albumin level of 3.5-3.9 mg/dl despite 7-point subjective global assessment in category A or a malnutrition inflammation score ≤5, were randomly assigned to receive IDAA by continuous infusion or acute load for 3 months. In continuous infusion (n = 24), 50% glucose followed by 7.2% branched-chain enriched AA solution were instilled in the first 15 minutes after HD initiation with high-flux dialyser through the e

SUBMITTER: Dumrongsukit S 

PROVIDER: S-EPMC11852333 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature