Albuminuria after induction treatment and kidney prognosis in ANCA-associated glomerulonephritis.

ABSTRACT:

Introduction

It remains unclear whether persisting proteinuria in ANCA-associated glomerulonephritis (AAGN) reflects damage from the initial injury or ongoing inflammation.

Methods

A retrospective, single-centre study of biopsy-proven AAGN was performed. The study defined the 'albuminuria' group as urine albumin-to-creatinine ratio (ACR) >300 mg/g and the 'no albuminuria' group as ACR ≤300 mg/g at 6 months. We sought the clinical and histopathological characteristics of both the initial and subsequent biopsies and long-term kidney outcomes stratified by albuminuria levels.

Results

Two hundred and eighteen patients were included. Within the first 6 months, 28 (13%) died or progressed to end-stage kidney disease (ESKD). Among the remaining 190 patients, 37% had an ACR >

SUBMITTER: Chalkia A 

PROVIDER: S-EPMC11852340 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature