Identification of 16 novel Alzheimer's disease loci using multi-ancestry meta-analyses.

ABSTRACT:

Introduction

Alzheimer's disease (AD) is the most prevalent form of dementia. While many AD-associated genetic determinants have been identified, few studies have analyzed individuals of non-European ancestry.

Methods

We conducted a multi-ancestry genome-wide association study (GWAS) of clinically diagnosed AD and AD-by-proxy using whole genome sequencing data from the National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site (NIAGADS), National Institute of Mental Health, UK Biobank (UKB), and All of Us (AoU) consisting of 49,149 cases (12,074 clinically diagnosed and 37,075 AD-by-proxy) and 383,225 controls. Nearly half of NIAGADS and AoU participants were of non-European ancestry.

Results

For clinically diagnosed AD, we identified 14 new loci-fi

SUBMITTER: Willett JDS 

PROVIDER: S-EPMC11852348 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature