Mechanisms of comorbidity between Alzheimer's disease and pain.

ABSTRACT: Clinical studies have revealed a significant correlation between pain and neurodegenerative diseases, particularly Alzheimer's disease (AD). However, due to cognitive and speech impairments, AD patients, especially those in moderate to severe stages, are often overlooked in pain management. The challenges in obtaining pain-related information from this population exacerbate the issue. Although recent clinical research has increasingly recognized the comorbidity of AD and pain, the pathological alterations and interactive mechanisms underlying this relationship remain inadequately explored. This review provides a comprehensive analysis of the clinical features and pathological mechanisms of AD with and without pain comorbidity. It examines underlying processes, including neuroinflammation,

SUBMITTER: Yao K 

PROVIDER: S-EPMC11852355 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature