Folic Acid Supplementation Inhibits Proliferative Retinopathy of Prematurity.

ABSTRACT:

Background

Retinopathy of prematurity (ROP) is the major cause of blindness in children. It is a biphasic disease with retinal vessel growth cessation and loss (Phase I) followed by uncontrolled retinal vessel growth (Phase II). Folate is an essential nutrient for fetal development and growth. Premature infants have a high risk for folate deficiency. However, the contribution of folate to ROP risk remains unknown.

Methods

In mouse oxygen-induced retinopathy (OIR), the nursing dams were fed with a folic acid-deficient or control diet after delivery until the end of hyperoxia. Alternatively, pups received direct injection of either folic acid or vehicle during Phase I hyperoxia. Genes involved in the folate cycle and angiogenic responses were examined using real-time PCR. Tota

SUBMITTER: Nian S 

PROVIDER: S-EPMC11852370 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature