<i>WBP5</i> Expression Influences Prognosis and Treatment Response in Head and Neck Squamous Cell Carcinoma.

ABSTRACT:

Objectives

Head and neck squamous cell carcinoma (HNSCC) is characterized by complex genetic alterations. This study aimed to identify WBP5 as a promising therapeutic target and evaluate the effect of WBP5 expression on prognosis and treatment response in HNSCC.

Methods

Publicly available datasets were comprehensively analyzed to investigate WBP5 expression through comprehensive bioinformatics analysis and functional validation.

Results

WBP5 was particularly overexpressed in HNSCC, as analyzed through the Gene Expression Profiling Interactive Analysis version 2 (GEPIA2) database and validated using multiple Gene Expression Omnibus (GEO) datasets. Analysis with UALCAN confirmed that WBP5 expression was significantly higher in advanced

SUBMITTER: Jeong EJ 

PROVIDER: S-EPMC11852431 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature