A Comparison of the Brain Parameters of Thais with Normal Cognition, Mild Cognitive Impairment, and Dementia.

ABSTRACT:

Objectives

This study examined the differences in brain volume and cortical thickness among individuals with normal cognition (NC) and those with NCDs, including mild cognitive impairment (MCI) and dementia. The aim was to identify the brain parameters supporting clinical decision-making for NCDs.

Method

A total of 116 participants were categorized into dementia, MCI, and NC groups, and their brain scans using structural magnetic resonance imaging (MRI) were processed and automatedly analyzed with FreeSurfer to obtain the absolute brain volume, volume normalized by intracranial volume (ICV), and cortical thickness. Patients with dementia exhibited a significantly smaller brain volume and cortical thickness than the MCI and NC groups.

Results

The left amygdala/ICV rati

SUBMITTER: Wisetwongsa P 

PROVIDER: S-EPMC11852455 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature