Blood-Based EWAS of Asthma Polygenic Burden in The Netherlands Twin Register.

ABSTRACT: Asthma, a chronic respiratory condition characterized by airway inflammation, affects millions of individuals worldwide. Challenges remain in asthma prediction and diagnosis from its complex etiology involving genetic and environmental factors. Here, we investigated the relationship between genome-wide DNA methylation and genetic risk for asthma quantified via polygenic scores in two cohorts from the Netherlands Twin Register; one enriched with asthmatic families measured on the Illumina EPIC array (n = 526) and a general population cohort measured on the Illumina HM450K array (n = 2680). We performed epigenome-wide association studies of asthma polygenic scores in each cohort with results combined through meta-analysis (total samples = 3206). The EWAS meta-analysis identified 63 significa

SUBMITTER: Van Asselt AJ 

PROVIDER: S-EPMC11852504 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature