Sex and Strain-Specific Variations in Motor Recovery Following Compression Spinal Cord Injury: Comparison of Sprague-Dawley and Wistar Rats.

ABSTRACT: Background/Objectives: Prior studies have noted varied, spontaneous motor recovery in rat strains after spinal cord injury (SCI), but systematic comparisons of different locomotor measurements across different severity and sexes are lacking. Hence, we quantified hindlimb utilization in male and female Sprague-Dawley (SD) and Wistar rats following moderate and severe SCI. Methods: Compression SCI was induced using a 15-g clip for 180 s for moderate SCI or a 50-g aneurysm clip for 60 s for severe SCI in male and female SD and Wistar rats. Measures of locomotor performance using the Basso-Beattie-Bresnahan (BBB), CatWalk gait analysis, and horizontal ladder tests were taken postoperatively and weekly for seven weeks. Results: BBB scores indicated greater spontaneous recov

SUBMITTER: Mojarad N 

PROVIDER: S-EPMC11852505 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature