Deoxycholic acid ameliorates obesity and insulin resistance by enhancing lipolysis and thermogenesis.

ABSTRACT:

Background

Bile acids are essential for energy metabolism. Deoxycholic acid (DCA) in particular is associated with metabolic disorders such as type 2 diabetes mellitus (T2DM) and obesity. However, the direct effects of DCA on metabolism and body composition have yet to be studied in depth.

Methods

Targeted metabolomics analysis of human feces was performed. C57BL/6J mice fed a high-fat diet (HFD) were gavaged with DCA, and the effects were measured by metabolic tolerance tests and metabolic cages. Body composition was evaluated by echoMRI. To evaluate the beneficial function of DCA on thermogenesis and lipolysis, histological staining and qPCR were carried out.

Results

There was negative correlation between fecal DCA levels and serum glucose levels, as well as the Hom

SUBMITTER: Tuerhongjiang G 

PROVIDER: S-EPMC11852518 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature