Hyper-porous encapsulation of microbes for whole cell biocatalysis and biomanufacturing.

ABSTRACT: Biocatalysis using whole cell biotransformation presents an alternative approach to producing complex molecules when compared to traditional synthetic chemical processes. This method offers several advantages, including scalability, self-contained co-factor recycling systems, the use of cost-effective raw materials, and reduced purification costs. Notably, biotransformation using microbial consortia provides benefits over monocultures by enhancing biosynthesis efficiency and productivity through division of labor and a reduction in metabolic burden. However, reliably controlling microbial cell populations within a consortium remains a significant challenge. In this work, we address this challenge through mechanical constraints. We describe the encapsulation and immobilization of cells in a

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11852520 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature