¹⁸F-MK-6240 tau PET in patients at-risk for chronic traumatic encephalopathy.

ABSTRACT:

Background

Molecular biomarkers of chronic traumatic encephalopathy (CTE) are lacking. We evaluated ¹⁸F-MK-6240 tau PET as a biomarker for CTE. Two studies were done: (1) ³H-MK-6240 autoradiography and an in-vitro brain homogenate binding studies on postmortem CTE tissue, (2) an in-vivo ¹⁸F-MK-6240 tau PET study in former American football players.

Methods

Autoradiography and in-vitro binding studies were done using ³H-MK-6240 on frozen temporal and frontal cortex tissue from six autopsy cases with stage III CTE compared to Alzheimer's disease. Thirty male former National Football League (NFL) players with cognitive concerns (mean age = 58.9, SD = 7.8) completed tau (¹⁸F-MK-6240) and Aβ (¹⁸F-Florbetapir) PET.

SUBMITTER: Alosco ML 

PROVIDER: S-EPMC11852567 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature