Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer's Treatment: Systematic Review.

ABSTRACT:

Introduction

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory loss and cognitive decline, primarily due to dysfunction of acetylcholine caused by acetylcholinesterase and butyrylcholinesterase. While synthetic cholinesterase inhibitors like donepezil, rivastigmine, and galantamine are commonly used, they have notable side effects, prompting interest in natural alternatives. Medicinal plants, rich in bioactive compounds like flavonoids and alkaloids, have shown potential as cholinesterase inhibitors with additional antioxidants and anti-inflammatory benefits. This study aimed to evaluate the cholinesterase-inhibiting effects of various plant species and their compounds to identify new therapeutic candidates and reduce side effects.

Method

A PRI

SUBMITTER: ALNasser MN 

PROVIDER: S-EPMC11852592 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature