Optimized Extraction Method for Neutral Cannabinoids Quantification Using UHPLC-HRMS/MS.

ABSTRACT: The Cannabis market is experiencing steady global growth. Cannabis herbal extracts (CHE) are interesting and sought-after products for many clinical conditions. The medical potential of these formulations is mainly attributed to neutral cannabinoids, such as cannabidiol (CBD), tetrahydrocannabinol (THC), and cannabinol (CBN), and their non-standardized content poses a significant fragility in these pharmaceutical inputs. High-resolution mass spectrometry portrays a powerful alternative to their accurate monitoring; however, further analytical steps need to be critically optimized to keep up with instrumental performance. In this study, Full Factorial and Box-Behnken designs were employed to achieve a multivariate optimization of CBD, THC, and CBN extraction from human and vet

SUBMITTER: Meirelles JV 

PROVIDER: S-EPMC11852687 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature