Mitochondrial injury and complement dysregulation are drivers of pathological inflammation in viral myocarditis.

ABSTRACT: Enteroviruses cause nearly 1 billion global infections annually and are associated with a diverse array of human illnesses. Among these, myocarditis and the resulting chronic inflammation have been recognized as major contributing factors to virus-induced heart failure. Despite our growing understanding, very limited therapeutic strategies have been developed to address the pathological consequences of virus-induced chronic innate immune activation. Coxsackievirus B3 (CVB3) was used as a model cardiotropic enterovirus. We leveraged in vitro cell-based studies to investigate cardiomyocyte and macrophage interaction during CVB3 infection, as well as animal studies and unique human cardio specimens to evaluate mechanisms of viral heart injury. We present evidence that viral myocarditis

SUBMITTER: Mohamud Y 

PROVIDER: S-EPMC11852726 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature