Catestatin and Advanced Glycation End-Products: Potential Indicators of Cardiovascular Risk in Hashimoto's Thyroiditis.

ABSTRACT: Accumulating evidence suggests that overt hypothyroidism is associated with accelerated atherosclerosis, thereby increasing the risk for major cardiovascular events. The present study aimed to investigate the associations between serum catestatin levels and advanced glycation end-products (AGEs), indicators of vascular health, in individuals with Hashimoto's thyroiditis compared to healthy controls. A total of 100 female patients with Hashimoto's thyroiditis and 100 age-matched healthy controls were included in the study. Serum catestatin levels (10.2 (6.5-15.8) vs. 6.4 (4.1-9.3) ng/mL, p < 0.001) and tissue levels of AGEs (2.21 ± 0.55 ng/mL vs. 1.89 ± 0.56, p < 0.001) were both significantly higher in the Hashimoto's group compared to the healthy age-matched controls. A posi

SUBMITTER: Punda P 

PROVIDER: S-EPMC11852764 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature