Virus-like particle-based vaccines targeting the <i>Anopheles</i> mosquito salivary protein TRIO.

ABSTRACT: Malaria is a highly lethal infectious disease caused by Plasmodium parasites. These parasites are transmitted to vertebrate hosts when mosquitoes of the Anopheles genus probe for a blood meal. Sporozoites, the infectious stage of Plasmodium, transit to the liver within hours of injection into the dermis. Vaccine efforts are hindered by the complexity of the parasite's lifecycle and the speed at which the infection is established in the liver. In an effort to enhance immunity against Plasmodium, we produced a virus-like particle (VLP)-based vaccine displaying an epitope of TRIO, an Anopheles salivary protein that has been shown to enhance mobility and dispersal of sporozoites in the dermis. Previous work demonstrated that passive immunization with TRIO off

SUBMITTER: Francian A 

PROVIDER: S-EPMC11852919 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature