Signal Differentiation of Moving Magnetic Nanoparticles for Enhanced Biodetection and Diagnostics.

ABSTRACT: Magnetic nanoparticles are extensively utilized as markers/signal labelling in various biomedical applications. Detecting and distinguishing magnetic signals from similarly sized moving magnetic nanoparticles in microfluidic systems is crucial yet challenging for biosensing. In this study, we have developed an original method to detect and differentiate magnetic signals from moving superparamagnetic (SPM) and ferrimagnetic (FM) nanoparticles of comparable sizes. Our approach utilizes a highly sensitive magnetic-coil-based sensor that harnesses the combined effects of giant magnetoimpedance (GMI) and an LC-resonance circuit, offering performance superior to that of conventional GMI sensors. Iron oxide nanoparticles, which have similar particle sizes but differing coercivities (zero for SPM

SUBMITTER: Hwang KY 

PROVIDER: S-EPMC11852982 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature