Determining Ligand Binding and Specificity Within the β₂-Integrin Family with a Novel Assay Platform.

ABSTRACT: The family of the β₂-integrin receptors is critically involved in host defense and homeostasis, by mediating immune cell adhesion, migration, and phagocytosis. Due to their key roles in immune surveillance and inflammation, their modulation has been recognized as an attractive drug target. However, the development of therapeutics has been limited, partly due to the high promiscuity of endogenous ligands, their functional responses, and gaps in our understanding of their disease-related molecular mechanisms. The delineation of the molecular role of β₂ integrins and their ligands has been hampered by a shortage of validated assay systems. To facilitate molecular and functional studies on the β₂-integrin family, and to enable screening of modulators, this stud

SUBMITTER: Sommer-Pluss CJ 

PROVIDER: S-EPMC11853025 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature