Lyophilized Small Extracellular Vesicles (sEVs) Derived from Human Adipose Stem Cells Maintain Efficacy to Promote Healing in Neuronal Injuries.

ABSTRACT: Background: Traumatic brain injury (TBI) occurs in individuals of all ages, predominantly during sports, accidents, and in active military service members. Chronic consequences of TBI include declined cognitive and motor function, dementia, and emotional distress. Small extracellular vesicles (sEVs), previously referred to as exosomes, are nano-sized lipid vesicles that play a role in intercellular communication. Our prior research established the efficacy of sEVs derived from human adipose stem cells (hASC sEVs) in accelerating the healing of brain injuries. The hASC sEVs are a biologic therapeutic and need to be stored at -20 °C or -80 °C. This limits their use in translating to everyday use in clinics or their inclusion in first-aid kits for application immediately after injury.

SUBMITTER: Jones B 

PROVIDER: S-EPMC11853053 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature