Quorum sensing inhibits phage infection by regulating biofilm formation of <i>P. aeruginosa</i> PAO1.

ABSTRACT: Quorum sensing (QS) can regulate diverse critical phenotypic responses in Pseudomonas. aeruginosa (P. aeruginosa), enabling bacterial adaptation to external environmental fluctuations and optimizing population advantages. While there is emerging evidence of QS's involvement in influencing phage infections, our current understanding remains limited, necessitating further investigation. In this study, we isolated and characterized a novel phage designated as BUCT640 that infected P. aeruginosa PAO1. This phage belonged to class Caudoviricetes, genus Bruynoghevirus, with a podovirus morphology, and its adsorption was dependent on Psl polysaccharides, a repeating pentamer used to support biofilm structure. Leveraging phage BUCT640 as a model, we analyzed the

SUBMITTER: Cao L 

PROVIDER: S-EPMC11853092 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature