A Genetic and Environmental Analysis of Inflammatory Factors in Chronic Widespread Pain Using the TwinsUK Cohort.

ABSTRACT: Chronic widespread musculoskeletal pain (CWP), a significant health issue affecting individuals and society, is often diagnosed as part of fibromyalgia but is not generally considered inflammatory. This study investigated the relationship between blood-based inflammatory factors and CWP in 904 individuals from the TwinsUK cohort. Participants, free of major inflammatory conditions, completed questionnaires to assess CWP. Plasma samples were analysed using the Olink panel, alongside assays for C-reactive protein (CRP) and Apolipoproteins A1 and B. No significant associations were observed between CWP and inflammatory factors after adjusting for multiple testing. Twin modelling revealed significant heritability for both CWP and inflammatory factors, with genetic covariance observed between C

SUBMITTER: Cherny SS 

PROVIDER: S-EPMC11853120 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature