CXCL12 as a Potential Hub Gene for N-Acetylcysteine Treatment of T1DM Liver Disease.

ABSTRACT: The etiology of type 1 diabetes mellitus (T1DM) is intricate, leading to its classification as an autoimmune metabolic disorder. T1DM often coexists with various visceral diseases. N-acetylcysteine (NAC) is widely acknowledged for its potent antioxidant properties. Studies have demonstrated that the combination of NAC and insulin can effectively alleviate iron-induced nephropathy in T1DM and mitigate oxidative stress injury in skeletal muscle associated with the condition. However, the potential impact of NAC alone on liver disease in individuals with T1DM remains uncertain. In this study, a beagle model was established to simulate T1DM, enabling investigation into the role of NAC in liver disease using RNA-seq biogenic analysis and subsequent validation through molecular biological method

SUBMITTER: Zhao M 

PROVIDER: S-EPMC11853168 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature