Risk Assessment Models for Predicting Venous Thromboembolism in Patients with Pancreatic Cancer.

ABSTRACT:

Background

Data on the performance of the Khorana, PROTECHT, and ONKOTEV risk assessment models (RAMs) to predict venous thromboembolism (VTE) in patients with pancreatic cancer (PC) receiving outpatient chemotherapy remain limited. We performed a head-to-head comparison of these RAMs in patients with newly diagnosed PC enrolled in the nationwide, multicenter, and prospective BACAP cohort.

Methods

The Khorana, PROTECHT, and ONKOTEV scores were calculated at enrollment prior to chemotherapy. Patients were stratified into intermediate- and high-VTE-risk groups according to each RAM. The primary study outcome was VTE at a 6-month follow-up. The accuracy and discriminatory performance of the scores were assessed by calculating time-dependent Brier scores and c-indexes. Sub-distr

SUBMITTER: Frere C 

PROVIDER: S-EPMC11853169 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature