Vasectomy and prostate cancer risk: a pooled of cohort studies and Mendelian randomization analysis.

ABSTRACT:

Background

The relationship between vasectomy and the risk of prostate cancer (PCa) remains unclear, with observational studies reporting inconsistent results. To clarify this ambiguity, we embarked on a comprehensive investigation comprising both a meta-analysis and a Mendelian randomization (MR) study. This dual approach aimed to thoroughly examine not only the association but also the causality between undergoing a vasectomy and the subsequent risk of PCa.

Methods

Our systematic review meticulously examined cohort studies published until January 2024, employing a random effects model for the computation of relative risks (RR) and their 95% confidence intervals (CI). For MR Analysis, we leveraged aggregated data from the IEU Open GWAS database, investigating the correlatio

SUBMITTER: Wang L 

PROVIDER: S-EPMC11853223 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature