Roles of mediodorsal thalamus in observational fear-related neural activity in mouse anterior cingulate cortex.

ABSTRACT: Observational fear (OF) is the ability to vicariously experience and learn from another's fearful situation, enabling adaptive responses crucial for survival. It has been shown that the anterior cingulate cortex (ACC) and basolateral amygdala (BLA) are crucial for OF. A subset of neurons in the ACC is activated when observing aversive events in the demonstrator, which elicits OF. However, the neural circuit mechanisms underlying the expression of OF-related activity in the ACC remain unexplored. Previous studies have shown that the mediodorsal thalamus (MD) is crucial for OF, and MD neurons project to the ACC. Therefore, we hypothesize that the projection from MD to ACC may facilitate the OF-related activity in the ACC. By utilizing in vivo calcium imaging combined with the optogenetic ter

SUBMITTER: Ramesh K 

PROVIDER: S-EPMC11853286 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature