Enhanced Sensitivity Mach-Zehnder Interferometer-Based Tapered-in-Tapered Fiber-Optic Biosensor for the Immunoassay of C-Reactive Protein.

ABSTRACT: A Mach-Zehnder interferometer-based tapered-in-tapered fiber-optic biosensor was introduced in this paper. By integrating a micro-tapered fiber into a single tapered fiber structure, the design enhances sensitivity, signal-to-noise ratio, and resolution capability, while reducing the length of the sensing fiber. Through simulation analysis, it was found that the tapered-in-tapered fiber significantly improved the refractive index detection sensitivity by exciting a stronger evanescent field effect. The experimental comparison between the tapered-in-tapered fiber and traditional tapered fiber showed a 1.7-fold increase in sensitivity, reaching 3266.78 nm/RIU within the refractive index range of 1.3326 to 1.3414. Furthermore, to expand its application prospects in the biomedical field, gluta

SUBMITTER: Xiao L 

PROVIDER: S-EPMC11853398 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature