Methylation Biomarkers of Lung Cancer Risk: A Systematic Review and Meta-Analysis.

ABSTRACT: Background: Lung cancer (LC) is the leading cause of cancer deaths worldwide among both men and women, and represents a major public health challenge. DNA methylation (DNAm) has shown potential in identifying individuals at higher risk of LC, but the overall evidence has not been systematically evaluated. This review and meta-analysis aims to evaluate and summarize existing research on the association between blood DNAm levels and LC risk. Methods: Searches were conducted in PubMed, Web of Science, and Scopus for studies published until February 2024, following PRISMA and MOOSE guidelines. Eleven studies met the eligibility criteria. Results: Using a random effects model, our pooled analysis showed a significant association between increased DNAm levels and LC risk (OR

SUBMITTER: Dolcini J 

PROVIDER: S-EPMC11853407 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature