Comprehensive Analysis of Granzymes and Perforin Family Genes in Multiple Cancers.

ABSTRACT: Background/Objectives: Cancer remains a significant global health concern, with immunotherapies emerging as promising treatments. This study explored the role of perforin-1 (PRF1) and granzymes A, B and K (GZMA, GZMB and GZMK) in cancer biology, focusing on their impact on tumor cell death and immune response modulation. Methods: Through a comprehensive genomic analysis across various cancer types, we explored the differential expression, mutation profiles and methylation patterns of these genes, providing insights into their potential as therapeutic targets. Furthermore, we investigated their association with immune cell infiltration and pathway activation within the tumor microenvironment in each tumor type. Results: Our findings revealed

SUBMITTER: Mareboina M 

PROVIDER: S-EPMC11853441 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature