Molecular Testing as Triage in Cervical Cancer Screening: Economic Evaluation Using Headroom Analysis.

ABSTRACT: Background: Molecular triage testing for high-risk human papillomavirus (hrHPV)-based cervical cancer screening can be used in self-sampling, potentially reducing unnecessary colposcopies and increasing attendance. However, its commercial value remains underexplored. This study used headroom analysis to estimate the maximum reimbursable price (MRP) at which molecular testing would be cost-effective for the triage of hrHPV-positive women, compared with cytology. Methods: A validated microsimulation Markov model for the Dutch cervical cancer screening program evaluated three triage scenarios: (1) cytology (base scenario), (2) molecular testing in self-samples only (scenario I), and (3) molecular testing on self- and GP-collected samples (scenario II). Test sensitivity and speci

SUBMITTER: Castaneda KM 

PROVIDER: S-EPMC11853484 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature