Assessing the uptake of the core outcome set in randomized controlled trials for coronary artery disease: a trial registry analysis.

ABSTRACT:

Background

Coronary artery disease (CAD) is a global health crisis, responsible for nearly 20 million deaths annually worldwide and 12.6% of all deaths in the United States. Randomized controlled trials (RCTs) are critical for developing evidence-based clinical guidelines, but inconsistent outcome reporting across RCTs hinders evidence synthesis and comparability. In 2015, McNamara et al. introduced a CAD core outcome set (COS) to promote standardization in CAD trial outcomes. This study evaluates the uptake of the CAD COS in RCTs registered at ClinicalTrials.gov since its publication.

Methods

This trial registry analysis evaluated the uptake of the CAD COS in phase III/IV RCTs registered on ClinicalTrials.gov from May 2010 to June 2023. Trials were included if they assessed

SUBMITTER: Beerman S 

PROVIDER: S-EPMC11853499 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature