Well-Preserved Urinary Bladder Anatomy in Rats After Minimally Invasive Surgery.

ABSTRACT: Background: The setup of experimental protocols able to preserve the anatomical integrity also in terms of organ microarchitecture is mandatory to ensure result translatability. Also, the maintenance of structural integrity perfectly aligns with the refinement implementation aiming to reduce procedure severity, a key issue in animal studies deemed compulsory from both ethical and legal standpoints. Here we report a detailed description of all peri-operative and post-operative care and clinical evaluation in a surgical rat model to test the efficacy of a catheter functionalized by a peptide coating with antimicrobial and antibiofilm properties, whose efficacy was previously tested in vitro. Methods: We used male and female adult Fischer 344 rats (tot n = 44, n =

SUBMITTER: Giaquinto D 

PROVIDER: S-EPMC11853525 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature