DNA methylation at birth and IgE trajectories from birth to adolescence, different patterns between White and Asian.

ABSTRACT:

Aim

We aim to assess association of DNA methylation (DNAm) at birth with total immunoglobulin E (IgE) trajectories from birth to late adolescence and whether such association is ethnicity-specific.

Methods

We examined the association of total IgE trajectories from birth to late adolescence with DNAm at birth in two independent birth cohorts, the Isle of wight birth cohort (IOWBC) in UK (n = 796; White) and the maternal and infant cohort study (MICS) in Taiwan (n = 60; Asian). Biological pathways and methylation quantitative trait loci (methQTL) for associated Cytosine-phosphate-Guanine sites were studied.

Results

Two total IgE trajectories, high vs. low, were inferred from each of the two cohorts. Associations of DNAm at 103 CpGs with IgE trajectories in

SUBMITTER: Zhang H 

PROVIDER: S-EPMC11853557 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature