Pulmonary Arterial Hypertension-Induced Reproductive Damage: Effects of Combined Physical Training on Testicular and Epididymal Parameters in Rats.

ABSTRACT: Background/Objectives: Pulmonary arterial hypertension (PAH) affects the pulmonary vasculature and cardiac function. While its impact on target organs has been extensively studied, little is known about its effects on highly vascularized organs, such as those from the male reproductive system. This study explores the impact of PAH on testis and epididymis, evaluating the potential role of combined exercise training as a non-pharmacological strategy to mitigate alterations in these organs. Methods: Male Wistar rats (n = 8/group) were assigned to one of three groups: sedentary control, sedentary PAH, and exercise PAH. PAH was induced by monocrotaline administration (60 mg Kg^-1, i.p). The exercise PAH group underwent three weeks of combined physical training, i

SUBMITTER: Assis MQ 

PROVIDER: S-EPMC11853577 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature