Establishment and evaluation of a predictive model for immune reconstitution in people living with HIV after antiretroviral therapy.

ABSTRACT:

Background

Achieving complete immune reconstitution (CIR) in people living with human immunodeficiency virus (PLWH) following antiretroviral therapy (ART) is essential for preventing acquired immunodeficiency syndrome (AIDS) progression and improving survival. However, there is a paucity of robust prediction models for determining the likelihood of CIR in PLWH after ART. We aimed to develop and validate a CIR prediction model utilizing baseline data.

Methods

Baseline data including demographic information, immunological profiles, and routine laboratory test results, were collected from PLWH in Yunnan, China. Baseline referred to the first recorded results after HIV diagnosis but before initiating ART, and these initial measurements served as the baseline data for analysis. T

SUBMITTER: Li N 

PROVIDER: S-EPMC11853608 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature