Detection of an intestinal cell DNA methylation signature in blood samples from neonates with necrotizing enterocolitis.

ABSTRACT:

Background

Necrotizing enterocolitis (NEC) is an often fatal intestinal injury that primarily affects preterm infants for which screening tools are lacking. We performed a pilot analysis of DNA methylation in peripheral blood samples from preterm infants with and without NEC to identify potential NEC biomarkers.

Methods

Peripheral blood samples were collected from infants at NEC diagnosis (n = 15) or from preterm controls (n = 13). Targeted genome-wide analysis was performed to identify DNA methylation differences between cases and controls.

Results

Broad differences between NEC cases and controls were identified in distinct genomic elements. Differences between surgical NEC cases and controls were frequently associated with inflammation. Deconvolution a

SUBMITTER: Frazer L 

PROVIDER: S-EPMC11853613 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature