A Dual Nano-Signal Probe-Based Electrochemical Immunosensor for the Simultaneous Detection of Two Biomarkers in Gastric Cancer.

ABSTRACT: Detecting multiple tumor markers is of great importance. It helps in early cancer detection, accurate diagnosis, and monitoring treatment. In this work, gold nanoparticles-toluidine blue-graphene oxide (AuNPs-TB-GO) and gold nanoparticles-carboxyl ferrocene-tungsten disulfide (AuNPs-FMC-WS₂) nanocomposites were prepared for labeling Carcinoembryonic antigen (CEA) antibody and Carbohydrate antigen 72-4 (CA72-4) antibody, respectively, and used as two kinds of probes with different electrochemical signals. With the excellent magnetic performance of biotin immune magnetic beads (IMBs), the biofunctional IMBs were firmly deposited on the magnetic glassy carbon electrode (MGCE) surface by applying a constant magnetic field, and then the CEA and CA72-4 antibody were immobilized on the

SUBMITTER: Su LT 

PROVIDER: S-EPMC11853661 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature