Investigating Connectivity Gradients in Schizophrenia: Integrating Functional, Structural, and Genetic Perspectives.

ABSTRACT: Background: Schizophrenia is a complex disorder characterized by disruptions in cognition, behavior, and emotions. Extensive research has uncovered alterations in a single modality (either the brain structure or function) in schizophrenia. However, the limitation is that a single modality could not offer a synchronous result between the brain structure and function because of different samples. Here, a multiparametric approach is essential to understand the common and distinct alterations between the brain structure and function in schizophrenia. Methods: We analyzed structural and functional magnetic resonance imaging data from 146 participants (72 individuals with schizophrenia and 74 healthy controls). Individual morphological similarity and functional connectivity gradien

SUBMITTER: Xiang J 

PROVIDER: S-EPMC11853694 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature