Circular RNA ZNF277 Sponges miR-378d to Inhibit the Intracellular Survival of <i>Mycobacterium tuberculosis</i> by Upregulating Rab10.

ABSTRACT: Circular RNAs (circRNAs) are covalently closed non-coding RNAs formed by back-splicing, lacking a 5' cap and poly-A tail. They could act as important regulatory factors in the host's anti-tuberculosis immune process, but only a few have been identified, and their molecular mechanisms remain largely unclear. Here, we identified a novel circRNA, circ-ZNF277, which responds to Mycobacterium tuberculosis (Mtb) infection in THP-1 cells. Circ-ZNF277 binds microRNA-378d (miR-378d) in vivo. The expression level of circ-ZNF277 affects the clearance of the intracellular Mtb in THP-1 cells. Mechanistically, more circ-ZNF277 molecules could absorb more miR-378d, thereby competitively activating the NF-κB signaling pathway, promoting the release of pro-inflammatory cytokines includ

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC11853707 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature