Probing Solid-Binding Peptide Self-Assembly Kinetics Using a Frequency Response Cooperativity Model.

ABSTRACT: Biomolecular adsorption has great significance in medical, environmental, and technological processes. Understanding adsorption equilibrium and binding kinetics is essential for advanced process implementation. This requires identifying intrinsic determinants that predict optimal adsorption properties at bio-hybrid interfaces. Solid-binding peptides (SBPs) have targetable intrinsic properties involving peptide-peptide and peptide-solid interactions, which result in high-affinity material-selective binding. Atomic force microscopy investigations confirmed this complex interplay of multi-step peptide assemblies in a cooperative modus. Yet, most studies report adsorption properties of SBPs using non-cooperative or single-step adsorption models. Using non-cooperative kinetic models for predict

SUBMITTER: Bader T 

PROVIDER: S-EPMC11853711 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature