Maternal Resveratrol Supplementation Attenuates Prenatal Stress Impacts on Anxiety- and Depressive-like Behaviors by Regulating Bdnf Transcripts Expression in the Brains of Adult Male Offspring Rats.

ABSTRACT:

Background

Prenatal stress has been reported to harm the physiological and biochemical functions of the brain of the offspring, potentially resulting in anxiety- and depression-like behaviors later in life. Trans-Resveratrol (RESV) is known for its anti-inflammatory, anxiolytic, and antidepressant properties. However, whether administering RESV during pregnancy can counteract the anxiety- and depression-like behaviors induced by maternal stress is unknown.

Objective

This study aimed to assess the protective potential of RESV against molecular and behavioral changes induced by prenatal stress.

Methods

During pregnancy, the dams received 50 mg/kg BW/day of RESV orally. They underwent a movement restriction for forty-five minutes, three times a day, in addition to being

SUBMITTER: Vera-Juarez G 

PROVIDER: S-EPMC11853727 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature