Impact of the polygenic risk scores for attention-deficit/hyperactivity disorder in Alzheimer's disease.

ABSTRACT:

Introduction

Epidemiological studies indicate a link between attention-deficit/hyperactivity disorder (ADHD) and elevated risk of dementia. However, the impact of ADHD on cognition and Alzheimer's disease (AD) biomarkers in individuals with cognitive impairment remains unclear.

Methods

We computed weighted ADHD polygenic risk scores (ADHD-PRS) in 938 cognitively impaired participants (674 mild cognitive impairment [MCI] and 264 dementia; mean age 73.5 years). A subset underwent cerebrospinal fluid (CSF) analysis for amyloid beta (Aβ) and phosphorylated tau, as well as fluorodeoxyglucose positron emission tomography ([¹⁸F]FDG-PET).

Results

We observed lower executive function in individuals with high ADHD-PRS for both MCI and dementia participants. Higher le

SUBMITTER: Leffa DT 

PROVIDER: S-EPMC11853731 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature