Spatial transcriptomic analysis of tumor microenvironment in esophageal squamous cell carcinoma with HIV infection.

ABSTRACT:

Background

Human Immunodeficiency Virus (HIV) is one of the most prevalent viruses, causing significant immune depletion in affected individuals. Current treatments can control HIV and prolong patients' lives, but new challenges have emerged. Increasing incidence of cancers occur in HIV patients. Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers observed in HIV patients. However, the spatial cellular characteristics of HIV-related ESCC have not been explored, and the differences between HIV-ESCC and typical ESCC remain unclear.

Methods

We performed spatial transcriptome sequencing on HIV-ESCC samples to depict the microenvironment and employed cell communication analysis and multiplex immunofluorescence to investigate the molecular mechanism in HIV-

SUBMITTER: Zuo Y 

PROVIDER: S-EPMC11853777 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature