Seasonal Influences on Human Placental Transcriptomes Associated with Spontaneous Preterm Birth.

ABSTRACT: Demographic studies have revealed a strong association between exposure to high ambient temperatures during pregnancy and increased risks of preterm birth (PTB). The mechanism underlying this association is unclear, but it is plausible that altered placental function may contribute to it. In this study, we conducted differential gene expression analysis, gene set enrichment analysis (GSEA), and gene ontology (GO) analysis on bulk RNA-seq data from human placentas delivered at term and preterm during the warmer months compared to placentas delivered at term and preterm during the colder months in the UK. We detected 48 differentially expressed genes in preterm placentas delivered during the warmer months compared to preterm placentas delivered during the colder months, the majority of which

SUBMITTER: Akram KM 

PROVIDER: S-EPMC11853885 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature