Proteome-wide Mendelian randomization identifies causal plasma proteins in prostate cancer development.

ABSTRACT:

Background

The etiology of prostate cancer remained elusive, whether plasma protein levels are associated with prostate cancer is still unknown.

Methods

We have performed Mendelian randomization analyses to calculate the causal effects of plasma proteins on the risk of prostate cancer in the PRACTICAL consortium dataset using cis-protein quantitative trait loci (cis-pQTL) variants as instrumental variables for plasma proteins, and cis-expression quantitative trait locus (cis-eQTL) for the circulating gene expression. We also replicated the findings in the FinnGen consortium.

Results

Genetically proxied levels of 4 plasma proteins (CREB3L4, HDGF, SERPINA3, GNPNAT1) were identified as positively correlated with an increased risk of prostate cancer, while an increase in

SUBMITTER: Wu J 

PROVIDER: S-EPMC11853923 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature