Neural indices of heritable impulsivity: Impact of the COMT Val158Met polymorphism on frontal beta power during early motor preparation.

ABSTRACT: Studies of COMT Val¹⁵⁸Met suggest that the neural circuitry subserving inhibitory control may be modulated by this functional polymorphism altering cortical dopamine availability, thus giving rise to heritable differences in behaviors. Using an anatomically-constrained magnetoencephalography method and stratifying the sample by COMT genotype, from a larger sample of 153 subjects, we examined the spatial and temporal dynamics of beta oscillations during motor execution and inhibition in 21 healthy Met¹⁵⁸/Met¹⁵⁸ (high dopamine) or 21 Val¹⁵⁸/Val¹⁵⁸ (low dopamine) genotype individuals during a Go/NoGo paradigm. While task performance was unaffected, Met¹⁵⁸ homozygotes demonstrated an overall increase in beta power across regions

SUBMITTER: Happer JP 

PROVIDER: S-EPMC11853962 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature