Radiation Retinopathy: Microangiopathy-Inflammation-Neurodegeneration.

ABSTRACT:

Purpose

Proton irradiation is used to treat choroidal melanoma of the eye. The impact on non-malignant retinal cells is currently understudied. Therefore, we here report a mouse model to investigate the impact of proton irradiation on the retina.

Methods

We performed a proton beam irradiation of 5-15 Cobalt-Gray-Equivalent (CGE) of the eyes of female C57Bl6/J (Cx3cr1^+/+), Cx3cr1^gfp/+ and Cx3cr1^gfp/gfp mice mimicking the clinical situation and evaluated the structure, function and cellular composition of the retina up to 24 weeks after irradiation.

Results

Proton beam irradiation of the eye with 15 CGE leads to cataract formation after 24 weeks without affecting the gross anatomy of the retinal vasculature as shown by Fundus imaging in

SUBMITTER: Davids AM 

PROVIDER: S-EPMC11853965 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature