HnRNPC triggers the degradation of MITA to suppress the interferon-mediated antiviral response.

ABSTRACT: Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a group of 34-120 kDa nuclear proteins that have recently been reported to participate in virus replication. The hnRNP family contains approximately 20 members, including hnRNP A1, hnRNP A2, hnRNP A2B1, hnRNPC, hnRNPD and hnRNPK. HnRNPC plays important roles in RNA biology, including expression, stability, mRNA splicing, nonspecific sequence export and 3'-end processing; however, the mechanisms underlying hnRNPC regulatory roles are not fully understood. Here, we found that zebrafish hnRNPC promoted spring viraemia of carp virus (SVCV) replication by increasing the stability of SVCV phosphoprotein while inhibiting the K48-linked ubiquitination of virus phosphoprotein, thereby suppressing the type I interferon (IFN) response. Mechanistic

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11854013 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature